Ara Parseghian Medical Research Foundation

Join us in the Fight Against Niemann-Pick Type C Disease

Research

Research

Previously Funded Grants as of 7/1/09

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  1. Christopher Austin, M.D. – Director, National Institutes of Health, Chemical Genomics Center – TITLE:  “Identifying a Potential New Therapy for NP-C Patients by Screening of FDA-Approved Drugs” 
  2. David Azorsa, Ph.D. – Senior Investigator, Pharmaceutical Genomics, Translational Genomics Research Institute (TGen) – TITLE:  “Application of Functional Genomics to Identify and Validate Genes that Restore Normal Cholesterol Transport in NP-C Cells”
  3. Philip Beachy, Ph.D. - Associate Professor, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine - $220,000 award (2-year grant from 1/98 - 12/99) TITLE: "Cholesterol homeostasis and NP-C: A role in cell signaling?"
  4. Krishna Bhat, Ph.D. – Emory University School of Medicine - $208,647 award (2-year grant from 7/01 – 6/03) TITLE:  “NPC disease in Drosophila mutant for the tumor suppressor Patched”
  5. Kendal Broadie, Ph.D. - Assistant Professor, Department of Biology, University of Utah - $250,000 award (2-year grant from 1/00 - 12/01) TITLE: "Neurological functions of NPC1 in Drosophila"
  6. Maja Bucan, Ph.D. - Assistant Professor, College of Medicine, University of Pennsylvania - $250,000 award (2-year grant from 7/95 - 6/97) TITLE: "Genetic Mapping and Isolation of the mouse NP-C Disease Gene"
  7. Robert Burgess, Ph.D. and Kevin Seburn, Ph.D. – The Jackson Laboratory – $5,000 award (1-year grant from 4/06 – 3/07) TITLE:  “Characterization and development of a new mouse model of NP-C disease”
  8. Eugene Carstea, Ph.D. - Senior Staff Fellowship Scientist, Developmental and Metabolic Neurology Branch, Neurology Institute, NIH - $250,000 award (2-year grant from 7/95 - 6/97) TITLE: "Integrative Efforts to Identify Gene for Niemann-Pick disease Type C"
  9. Geoffrey Chang, Ph.D. - Associate Professor, The Scripps Research Institute - $96,000 award (1.5- year grant from 07/05-12/06) TITLE: "X-ray Structure of Niemann-Pick C1"
  10. T.Y. Chang, Ph.D. - Professor of Biochemistry, Dartmouth Medical School - $151,844 award (2-year grant from 1/00 - 12/01) TITLE: "Role of NPC1 in Intracellular Cholesterol Trafficking"
  11. David Craig, Ph.D. – Associate Investigator, Neurogenomics, Translational Genomics Research Institute (TGen) – $47,073 award(1-year grant from 7/06 – 6/07)  – TITLE:  “Identification of the mechanism of allopregnanolone-mediated neuroprotection in Niemann-Pick Type C disease”
  12. Kumlesh Dev, Ph.D. –Laboratory Head of Molecular and Cellular Neuroscience, Novartis Pharma A.G., Switzerland – TITLE: “Identification of Molecular Targets Linking Alzheimer’s disease and Niemann-Pick Type C disease.”
  13. Robert Erickson, M.D. - Professor of Human Genetics and Inherited Diseases, University of Arizona College of Medicine - $141,666 award (2.5-year grant from 7/97 - 12/99) TITLE: "Cloning the Mouse Homolog of the Niemann-Pick C Gene"
  14. William Garver, Ph.D. - Research Assistant Professor, Department of Pediatrics, University of Arizona – $285,009 award (5.5-year grant from 1/01 – 6/06) TITLE: "Research Projects for the Investigation of Niemann-Pick Type C disease”
  15. Robert Gillies, Ph.D. - Professor, Biochemistry, University of Arizona College of Medicine - $157,465 award (2-year grant from 1/99 - 12/00) TITLE: “Non-invasive Monitoring of NP-C Progression and Therapy with MRS/MRI"
  16. Wenda Greer, Ph.D. - Associate Professor, Pathology Department, Dalhousie University, Halifax, Nova Scotia - $75,000 award (1-year grant from 8/96 - 7/97)
    TITLE: "Localizing the Niemann-Pick D Gene (Nova Scotia Variant of Type C)"
  17. Richard Hawkes, Ph.D. - Professor, Department of Cell Biology & Anatomy, University of Calgary - $152,760 award (2-year grant from 1/00 - 12/01) TITLE: "Patterned Purkinje Cell Loss in the Cerebellum of a Murine Model of NPC: A Possible Neuroprotective Role for the Small Heat Shock Protein HSP25"
  18. Elina Ikonen, M.D., Ph.D. - Senior Scientist of the Academy of Finland, National Public Health Institute, Helsinki, Finland - $347,500 award (2-year grant from 1/99 – 12/00) (1.5-year grant from 7/02 –12/03) (additional grant from 1/00 – 12/01) TITLE: "NPC lesion at the crossing of cellular cholesterol trafficking circuits"
  19. Rodney Infante, Ph.D. – NP-C Fellowship – UT Southwestern Medical Center at Dallas – TITLE:  “Biochemical Characterization of NPC1 and NPC2”
  20. Yiannis Ioannou, Ph.D. - Mt. Sinai School of Medicine - $250,000 award (2-year grant from 7/02 – 6/04) (Additional 6 years of awards totaling $719,902 from 3/96 – 6/02) TITLE:  “Cellular and Molecular Studies of Niemann-Pick C Disease”
  21. Barbara Karten, Ph.D. – Assistant Professor, Biochemistry and Molecular Biology, Dalhousie University, Canada – TITLE:  “The Role of NPC1 in Synaptic and Neuronal Function”
  22. Toshihide Kobayashi, Ph.D. - Group Leader, Sphingolipid Functions Laboratory, RIKEN Frontier Research System, Japan - $125,000 award (1-year grant from 1/01 - 12/01) TITLE: "Effects of cholesterol on endocytic pathway in NPC cells"
  23. Jeffrey Krise, Ph.D. – Assistant Professor, The University of Kansas – $125,000 award (1-year grant from 7/06 – 6/07) TITLE:  “The Role of NPC1 in the intracellular trafficking of endogenous amines”
  24. Yvonne Lange, Ph.D. - Professor, Department of Pathology, Rush Presbyterian - St. Lukes Medical Center - $103,796 award (1-year grant from 1/98 - 12/98) TITLE: "A Novel Treatment of Niemann-Pick Type C disease"
  25. Laura Liscum, Ph.D. - Professor, Physiology, Tufts University School of Medicine - $295,690 award (3.5-year grant from 8/97 - 12/00) TITLE: "Analysis of pharmaceutical compounds that correct the NPC phenotype in cultured cells"
  26. Emyr Lloyd-Evans, Ph.D. - Department of Biology, Oxford University – $46,000 award (6-month award during Fall 2005) TITLE:  “Lysosomal Calcium Homeostasis Defect in NPC1 Cells that contribute to Endocytic Defects in NPC1”
  27. Benny Liu, M.D. – NP-C Fellowship, UT Southwestern Medical Center at Dallas – TITLE: “Molecular Events Leading to Cell Death in the NP-C Syndrome”
  28. Robert Maue, Ph.D. - Associate Professor, Departments of Physiology and Biochemistry, Dartmouth Medical School - $279,950 award (2.5-year grant from 7/97 - 12/99) TITLE: "Striatal and hypothalamic neuron function in NP-C mice"
  29. Synthia Mellon, M.D. – Professor, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco - $537,500 award (4.5-year grant from 1/01 – 6/05) TITLE:  “Therapeutic Strategies for Treatment of NP-C”
  30. James Metherall, Ph.D. - Assistant Professor, Department of Human Genetics, University of Utah - $275,894 award (3-year grant from 8/95 - 7/98) TITLE: "Genetic Defects in Proteins Required for Intracellular Cholesterol Transport Cause NP-C"
  31. Gilles Millat, Ph.D. – Assistant Professor, INSERM and Lyon University, France – $112,200 award (2-year grant from 1/03 – 12/04)  TITLE:  “Generation of mice with specific mutations affecting the cysteine-rich luminal loop of the NPC1 protein”
  32. Haruaki Ninomiya, M.D. – Associate Professor, Neurobiology, Tottori University Faculty of Medicine, Japan – $50,000 award (1-year grant from 7/06 – 6/07)  TITLE:  “Quality Control and degradation mechanisms of NPC1”
  33. Axel Nohturfft, Ph.D. – Assistant Professor, Department of Molecular and Cellular Biology, Harvard University – $394,463 award (4.5-year grant from 1/01 – 6/05) TITLE:  “Role of apolipoprotein E in Niemann-Pick disease Type C”
  34. Daniel S. Ory, M.D. – Associate Professor, Internal Medicine, Washington University – TITLE: “Chemical Chaperone Therapy for NP-C Disease”
  35. Richard Pagano, Ph.D. and David Marks, Ph.D. – Professors, Department of Biochemistry & Molecular Biology, Mayo Clinic Rochester, MN – $708,349 awarded (7-year grant period from 1/98 – 6/04) TITLE: “Correction of NP-C Phenotype by Rab Overexpression”
  36. Leo Pallanck, Ph.D. - Assistant Professor, Genome Sciences, University of Washington – $306,866 award (4-year grant period from 7/02 – 6/06) TITLE:  “Development of a Drosophila Model of Niemann-Pick Type C Disease”
  37. William Pavan, Ph.D. - Section Chief, Laboratory of Genetic Disease Research, NIH - $246,060 award (3-year grant from 7/95 - 6/98) TITLE: "Exploiting Mouse Models to Identify the Gene for NP-C"
  38. David Pearce, Ph.D. - Assistant Professor, Biochemistry and Biophysics, University of Rochester School of Medicine & Dentistry - $83,187 award - (1-year grant from 1/00 - 12/00) TITLE: "A Yeast Model for Studying Niemann-Pick Type C"
  39. Suzanne Pfeffer, Ph.D. – Professor, Biochemistry, Stanford University School of Medicine – TITLE: “Molecular Analysis of  NPC1 Protein”
  40. Frank Pfrieger, Ph.D. – Assistant Professor, Centre de Neurochimie, Stasbourg, France - $200,000 award (2-year grant from 7/02 – 6/04) TITLE: “Role of NPC1 in cholesterol shuttle from Glia to Neurons”
  41. Frances Platt, Ph.D. – Reader of Glycobiology, University of Oxford - $499,052 award (4-year award from 7/02 – 6/06) TITLE: "Cell Biology of Niemann-Pick C disease: Role of glycosphingolipids in Pathology"
  42. Joyce Repa, Ph.D. – Assistant Professor, Physiology, UT Southwestern Medical Center at Dallas – TITLE:  “Nuclear Orphan Receptors as Targets for the Treatment of NP-C Disease”
  43. Matthew Scott, Ph.D. – Professor, Developmental Biology, Stanford University School of Med. – TITLE: "Functions of the NPC1 Protein in Purkinje Neurons"
  44. Frances Sharom, Ph.D. – Professor and Canada Research Chair, Molecular and Cellular Biology, University of Guelph, Canada – $407,858 award (5.5-year grant from 1/03 – 6/08) TITLE:  “Characterization of substrate binding, transport, lipid flippage and cholesterol transfer by the NPC1 protein”
  45. James Shayman, M.D. - Professor of Internal Medicine, University of Michigan $102,947 award - (1-year grant from 3/00 - 2/01) TITLE: "Treatment of NPC-1 with Glucosylceramide Synthase Inhibitors"
  46. Kyra L. Somers, D.V.M., Ph.D. – Assistant Professor, Microbiology, Immunology and Pathology, Colorado State University – $52,581 award (1-year grant from 7/2004 – 2/2005) TITLE:  “Feline Niemann-Pick C1 Disease”
  47. Ann Stock, Ph.D. - Professor, UMDNJ-Robert Wood Johnson Medical School Center for Advanced Biotechnology & Medicine & Associate Investigator, HHMI - $530,556 award (4.5-year grant from 1/03 – 6/07) TITLE: “Structural Analysis of NPC2”
  48. Judith Storch, Ph.D. – Professor, Nutritional Sciences, Rutgers University – TITLE: "Mechanisms of NPC2 Protein in Cholesterol Transport"
  49. Jerome Strauss III, Ph.D. - Professor, Obstetrics and Gynecology, University of Pennsylvania - $313,654 award (6-year award from 1/98 – 12/03) TITLE: "Function of MLN 64"
  50. Stephen Sturley, Ph.D. - Assistant Professor, Institute of Human Nutrition, Columbia University - $1,320,000 award (10-year grant from 8/97 – 6/07) TITLE: "A genetic model of Niemann-Pick Type C disease"
  51. Steve Sturley, Ph.D. – Associate Professor, Columbia University – TITLE:  “Modulating Niemann-Pick Type C Disease in Yeast, Mice and Humans”
  52. Derek Symula, Ph.D. – Research Scientist IV, Genomics Institute Wadsworth Center – TITLE: “Genetic Modifiers of NPC2 Deficiency in Mice.”
  53. Kinuko Suzuki, M.D. - Professor of Pathology and Laboratory Medicine, University of North Carolina - $203,247 award (2-year grant from 1/00 - 12/01)
    TITLE: "Neuronal death and glial cell reactions in NP-C mouse"
  54. Danilo Tagle, Ph.D. - Head - Molecular Neurogenetics Section, NIH - $83,000 award (1-year grant from 8/97 - 7/98) TITLE: "Characterization of the Niemann-Pick Type C Gene Product (NPC1)"
  55. Alan Tall, M.D. - Professor in Medicine, Columbia University - $200,200 award (2-year grant from 1/98 - 12/99) TITLE: "Atherosclerosis and Reverse Lipid Transport in NPC"
  56. James Thomas, Ph.D. - Professor, Department of Genetics, University of Washington - $120,000 award (2-year grant from 7/1/00 – 6/30/02) TITLE: “Genetic and Cellular Analysis of a C.elegans Model for Niemann-Pick Type C disease.”
  57. David H. Thompson, Ph.D. – Professor of Chemistry, Purdue University – TITLE: "Impact of HPbCD Polyrotaxanes on Inflammation in the NPC Mouse":
  58. Ted Trouard, Ph.D. - Associate Professor, Biomedical Engineering and Radiology, University of Arizona, - $17,000 award (Spring 2006) TITLE:  “Non-invasive Imaging to Detect and Monitor the Progression of NPC Disease and its Response to Therapy”
  59. Gerrit van Meer, Ph.D. – Professor, Membrane Enzymology, Utrecht University, The Netherlands – TITLE: “NPC1 Pumping Simple Glycosphingolipids”
  60. Jean Eaton Vance, Ph.D. - Professor, Heritage Medical Research Center, University of Alberta, Canada - $782,936 award (5.5 year grant from 1/00 – 6/06) TITLE: “Role of NPC1 in Primary Cultures of Murine Neurons”
  61. Kevin Vaughan, Ph.D. and Holly Goodson, Ph.D. – Associate and Assistant Professors, Biological Sciences, University of Notre Dame – $150,000 award (2-year grant from 7/06 – 6/08) TITLE: “Microtubule-Dependent Transport of NPC-Containing Membranes”
  62. Inez Vincent, Ph.D. – Research Associate Professor, Department of Pathology, University of Washington - $45,000 award (1-year grant from 1/1/03 – 12/31/03) TITLE:  “Cdk inhibitors for treating NPC.”
  63. Steven Walkley, D.V.M., Ph.D. – Professor, Neuroscience, Albert Einstein College of Medicine – TITLE:  “Gangliosides in the Pathogenesis of  NP-C”
  64. NP-C Genetic Counseling and Carrier Testing Center - Mayo Clinic, Rochester, MN - genetic counselor, Cate Walsh-Vockley
  65. Silvana Zanlungo, Ph.D. – Assistant Professor, Gastroenterology, Pontificia Universidad Catolica de Chile – TITLE:  “The Proapoptotic c-Abl Kinase as a Therapeutic Target for NP-C Disease”

 

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© 2008 Ara Parseghian Medical Research Foundation
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